A number of drugs are unstable in an aqueous environment, even when exposed for a short duration,so they are supplied in solid/dry form.Traditional dosage forms such as pills and capsules lack the dosing flexibility required in paediatric use and dysphagic conditions.Dry syrup preparations provides a solution for this delima. In dry syrup, drug is distributed in dry form and is converted in liquid form by adding (reconstitution) water. The principal advantage of this dosage form is that it overcomes the problem of instability in solution(viscosity changes,crystal growth,caking etc.).Powders for reconstitution are attractive over liquid oral dosage forms because of their compactness, which makes them more convenient for storage and transport.
Dry syrups are preparations consisting of solid, loose, dry particles of varying degrees of fineness. They contain one or more active ingredients, with or without excipients and, if necessary,authorized colouring agent and flavouring substances. They are generally administered in or with water or another suitable liquid. They may also be swallowed directly. They are presented as singledose or multidose preparations.Most oral suspension use tap water for reconstitution unless or otherwise specified.Most of the reconstituted suspnesion won't be stable for a long time.It shall not be used after specified time mentioned in the label.Most of the antibiotics have a short shelf life in liquid medium so they are often supplied as dry syrups.
Reconstitution, a pharmaceutical prerequisite for drysyrups, has direct implications on drug concentration, making it a critical parameter. Numerous intrinsic and extrinsic parameters affect the time and reproducibility of reconstitution of powders. Identification and control of these parameters during product development can reduce batch-to-batch variability in reconstitution time and provide confidence among the end users. A short and reproducible reconstitution time will also save the precious time and dose variability.
Hello, excellent article. Very apt description about the difference.
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