Sunday 26 February 2012

What is the difference between dissolution and disintegration


 
 
What is the difference between dissolution and disintegration?
 

 


Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions.

 
Where as dissolution is a process by which solid substance enters in the solvent to yield a solution. It is controlled by the affinity between the solid substance and the solvent.

 
In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.






Disintegration is a subset of dissolution.It is a process where by the oral dosage form falls apart or disintegrates in to smaller aggregates (disintegration is a disaggregation of constituent particles before dissolution happens).

 

Availability of a drug from the dosage form depends on it's ability to disintegrate fast enough in the existing dissolution media(Rate of drug dissolution is greatly influenced by disintegration of dosage form).

For pharmaceutical articles related to disintegration and dissolution, log on to pharmatreasures.blogspot.com

at

26 comments:

  1. Unknown9 September 2015 at 03:16

    Good posts, enjoyed to read and learn

    ReplyDelete
  2. NIMA27 September 2015 at 14:28

    nice thanks

    ReplyDelete
  3. Unknown12 November 2015 at 11:21

    Excellent

    ReplyDelete
  4. Unknown22 January 2016 at 13:13

    Nice clear explanation, thank you!

    ReplyDelete
  5. Unknown15 February 2016 at 09:00

    It's very good to clarify the basic concept with pictorial diagram

    ReplyDelete
  6. Unknown15 February 2016 at 09:01

    From rajesh jaiswal

    ReplyDelete
  7. Unknown27 March 2016 at 19:35

    I clarified u'r explanations.

    ReplyDelete
  8. jainia25 July 2016 at 06:25

    Thank you so much! This has helped me a lot :)

    ReplyDelete
  9. Unknown10 September 2016 at 04:19

    best

    ReplyDelete
  10. Unknown27 September 2016 at 02:10

    Good ans to me

    ReplyDelete
  11. Anonymous27 December 2016 at 01:17

    Thanks

    ReplyDelete
  12. Unknown29 December 2016 at 09:12

    Best. Thanks

    ReplyDelete
  13. Unknown29 December 2016 at 09:15

    Best. Thanks

    ReplyDelete
  14. Unknown5 January 2017 at 08:36

    thanks

    ReplyDelete
  15. Unknown28 March 2017 at 05:07

    Thanks...
    I have a question: what is the reason of using disk in disintegration test?

    ReplyDelete
  16. Sajid Hassan22 October 2017 at 04:29

    This comment has been removed by the author.

    ReplyDelete
  17. 9geritenews27 October 2017 at 08:19

    thanks

    ReplyDelete
  18. Unknown28 October 2017 at 04:14

    Positive site, where did u come up with the information on this posting?I have read a few of the articles on your website now, and I really like your style. Thanks a million and please keep up the effective work.
    monurol buy online

    ReplyDelete
  19. Unknown10 April 2018 at 06:18

    Humidity Sensor Signal Conditioning System - Takes small output from a humidity sensor, amplifies it, removes any offset voltage, corrects for gain error, digitizes and displays the relative humidity.

    national re-engineering project

    ReplyDelete
  20. Unknown12 August 2018 at 21:39

    Nice topic

    ReplyDelete
  21. Unknown2 September 2018 at 12:57

    good post

    Thank you

    ReplyDelete
  22. Unknown30 August 2019 at 05:56

    Thanks

    ReplyDelete
  23. Shagufta Ch4 October 2019 at 23:55

    Everlong Tablet

    Everlong Tablets in Karachi

    ReplyDelete
  24. Unknown12 August 2020 at 20:13

    Osm

    ReplyDelete
  25. Unknown14 January 2021 at 01:28

    What are the principal's and theory of dissolution

    ReplyDelete