Isolators
in Pharmaceutical Industry
|
In Pharmaceutical industry isolation technology
is either used to protect the product from the operator (ex: aseptic processes),
or protect the operator from the product (ex: potent product handling).
Isolator is a leak tight enclosure which acts as a physical
barrier and provides a workspace, which is separated from the surrounding
environment.
1. Closed Isolators – Isolators operated as closed systems do not exchange unfiltered air or contaminants with adjacent environments. Their ability to operate without personnel access to the critical zone makes isolators capable of levels of separation between the internal and external environment unattainable with other technologies. Because the effectiveness of this separation, closed isolators are ideally suited for application in the preparation of sterile and/or toxic material. Aseptic and Containment isolators are two types of closed isolators.
2. Open Isolators – Open isolators differ from closed isolators in that they are designed to allow for the continuous or semi-continuous egress of materials during operation, while maintaining a level of protection over the internal environment. Open isolators are decontaminated while closed, and then opened during manufacturing. Open isolators typically are used for the aseptic filling of finished pharmaceuticals.
The intent of isolators is to create an airtight barrier or enclosure around a piece of equipment or process which provides an absolute separation between the operator and product. The operator can perform tasks through half-suits or glove ports. Isolators provide a specific environment inside the isolator using HEPA filters. The environment can be positive pressure or negative, can have humidity control and oxygen control.
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