Prokinetic (gastroprokinetic/gastrokinetic/prokinetic) drug is a type of drug that promotes intestinal peristalsis. They are useful in the treatment of motility disorders in humans and other animals because they induce coordinated motility patterns.
A prokinetic drug enhances gastrointestinal motility by incresing the frequency of contractions in the small intestine or making them sronger without disturbing their rhythm.They are used to relive gastrointestinal symptoms such as abdominal discomfort,blotting,constipation,heartburn,nausea and vomitting.They are used to treat a number of gastrointestinal disorders, including irritable bowl syndrome,gastritis,acid reflux disease,gastroparesis and functional dyspepsia.
Pharmacodynamics
These drugs may increase acetylcholine concentrations by antagonizing the D2 recetor which inhibits acetylcholine release, or by inhibitting the enzyme acetyl cholinesterace which metabolizes acetylcholine. Higher acetylcholine levels increase gastrointestinal peristalsis and further increase pressure on the lower esophageal sphincter, thereby stimulating gastrointestinal motility, accelerating gastric emptying, and improving gastro-duodenal coordination.
Examples
Metoclopramide
Domperidone
Cisapride
Erythromycin
Ranitidine
Nitazidine
Neostigmine
Lidocaine
A prokinetic drug enhances gastrointestinal motility by incresing the frequency of contractions in the small intestine or making them sronger without disturbing their rhythm.They are used to relive gastrointestinal symptoms such as abdominal discomfort,blotting,constipation,heartburn,nausea and vomitting.They are used to treat a number of gastrointestinal disorders, including irritable bowl syndrome,gastritis,acid reflux disease,gastroparesis and functional dyspepsia.
Pharmacodynamics
These drugs may increase acetylcholine concentrations by antagonizing the D2 recetor which inhibits acetylcholine release, or by inhibitting the enzyme acetyl cholinesterace which metabolizes acetylcholine. Higher acetylcholine levels increase gastrointestinal peristalsis and further increase pressure on the lower esophageal sphincter, thereby stimulating gastrointestinal motility, accelerating gastric emptying, and improving gastro-duodenal coordination.
Examples
Metoclopramide
Domperidone
Cisapride
Erythromycin
Ranitidine
Nitazidine
Neostigmine
Lidocaine
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