Sunday, 26 February 2012

What is the difference between dissolution and disintegration

What is the difference between dissolution and disintegration?


Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions.

Where as dissolution is a process by which solid substance enters in the solvent to yield a solution. It is controlled by the affinity between the solid substance and the solvent.

In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.

Disintegration is a subset of dissolution.It is a process where by the oral dosage form falls apart or disintegrates in to smaller aggregates (disintegration is a disaggregation of constituent particles before dissolution happens).


Availability of a drug from the dosage form depends on it's ability to disintegrate fast enough in the existing dissolution media(Rate of drug dissolution is greatly influenced by disintegration of dosage form).

For pharmaceutical articles related to disintegration and dissolution, log on to


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  2. Good posts, enjoyed to read and learn

  3. Nice clear explanation, thank you!

  4. It's very good to clarify the basic concept with pictorial diagram

  5. Thank you so much! This has helped me a lot :)

  6. Thanks...
    I have a question: what is the reason of using disk in disintegration test?

  7. This comment has been removed by the author.

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