Sunday, 26 February 2012

What is the difference between dissolution and disintegration


 
 
What is the difference between dissolution and disintegration?
 

 


Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions.

 
Where as dissolution is a process by which solid substance enters in the solvent to yield a solution. It is controlled by the affinity between the solid substance and the solvent.

 
In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.






Disintegration is a subset of dissolution.It is a process where by the oral dosage form falls apart or disintegrates in to smaller aggregates (disintegration is a disaggregation of constituent particles before dissolution happens).

 

Availability of a drug from the dosage form depends on it's ability to disintegrate fast enough in the existing dissolution media(Rate of drug dissolution is greatly influenced by disintegration of dosage form).

For pharmaceutical articles related to disintegration and dissolution, log on to pharmatreasures.blogspot.com

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26 comments:

  1. Unknown9 September 2015 at 03:16

    Good posts, enjoyed to read and learn

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  2. NIMA27 September 2015 at 14:28

    nice thanks

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  3. Unknown12 November 2015 at 11:21

    Excellent

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  4. Unknown22 January 2016 at 13:13

    Nice clear explanation, thank you!

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  5. Unknown15 February 2016 at 09:00

    It's very good to clarify the basic concept with pictorial diagram

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  6. Unknown15 February 2016 at 09:01

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  7. Unknown27 March 2016 at 19:35

    I clarified u'r explanations.

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  8. jainia25 July 2016 at 06:25

    Thank you so much! This has helped me a lot :)

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  9. Unknown10 September 2016 at 04:19

    best

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  10. Unknown27 September 2016 at 02:10

    Good ans to me

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  11. Anonymous27 December 2016 at 01:17

    Thanks

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  12. Unknown29 December 2016 at 09:12

    Best. Thanks

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  13. Unknown29 December 2016 at 09:15

    Best. Thanks

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  14. Unknown5 January 2017 at 08:36

    thanks

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  15. Unknown28 March 2017 at 05:07

    Thanks...
    I have a question: what is the reason of using disk in disintegration test?

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    This comment has been removed by the author.

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  17. 9geritenews27 October 2017 at 08:19

    thanks

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    Nice topic

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  21. Unknown2 September 2018 at 12:57

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  25. Unknown14 January 2021 at 01:28

    What are the principal's and theory of dissolution

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