Pyrogens in Pharmaceutical Products
All microbes produce pyrogen; the most potent pyrogen comes from gram-negative bacteria. Humans react to pyrogen with fever, chills, headache, increased blood pressure and a constellation of other symptoms.
Fever Inducing Mechanism
1.Pyrogens entering in the blood stream binds to lipopolysaccharide binding protein (LPB).
2.LPB takes it in to the recticuloendothelial system (RES).
3.The receptor cells in the RES are circulating mononuclear cells.
4.This attachment to the receptor cells induces the production of proinflammatory cytokines.
5.These cytokines are interleukin1 &6 and tumour necrosis factor. These factors produces inflammation and fever.