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In Aspirin Tablets Magnesium Stearate Won't Be Used As a
Lubricant Why?
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1.
Stearate salts reacts with aspirin to
form corresponding salts of aspirin (especially calcium and magnesium salts),
resulting increased solubility of aspirin and establishing a higher pH. pH
change may be responsible for the stearate induced decomposition and this will
affect the stability of the product.
2.
When magnesium stearate is used as a
lubricant in aspirin formulation, it will affect the powder flow and content
uniformity of the tablet.
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